Echo 650 Series Acoustic Liquid Handlers

  • Enables assay miniaturization in a broad range of applications
  • Transfer from 384-well and 1536-well microplates
  • Accurate, precise, contact-free acoustic transfer in volumes as low as 2.5 nL
  • Transfer from Echo Qualified sample tubes* and microplates
  • Read more about Echo Acoustic Technology here

* Available for tube-enabled models

Explore Echo 650 Series Models

Another Step Forward for Acoustic Liquid Handling

Echo 650 Series Acoustic Liquid Handlers are ideal for high-throughput applications. They enables the transfer of as little as 2.5 nL from 384-well and 1536-well microplates. As your research needs change, upgrade packages are available that enable the addition of Echo Qualified sample tube capabilities.

Echo 650 Series Acoustic Liquid Handler Features

Key Benefits

  • Measure DMSO hydration levels to gain insights into sample integrity and improve transfer quality
  • Elimination of compound loss, cross-contamination, carryover, or leachates through non-contact transfer
  • Accurate and precise transfer of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs
  • Better results through direct dilution of compounds, an improvement over serial dilution methods
  • Flexibility to transfer any volume of liquid from any source well to any destination well

Acoustic Sample Tube Management

The FluidX AcoustiX Sample Tube (FAST) was developed in collaboration with and is sold by Brooks Life Sciences for ultra-high-density sample storage. The acoustic tube offers the following benefits:

  • Echo Qualified design - compatible with Echo 650T and 655T Liquid Handlers
  • Preserves sample integrity from storage to screen
  • Miniaturize upstream liquid handling steps to conserve sample
  • Rapidly pick sets of samples for targeted screening

Workflow Automation

To meet the broad spectrum of sample throughput needs, Echo 650 Series Liquid Handlers seamlessly integrate with the highly configurable Access™ Dual Robot System accommodating a wide variety of devices and enabling a fully automated workflow.

  • Configured to achieve optimal throughput for sample management workflows
  • Compact and ergonomic design with docking modules, turntables, retractable shelves, and drawers
  • Optional features can include environmental management to protect samples from hydration or evaporation
 

The New Sound of Sample Management

The Echo 655T Liquid Handler supports sample transfer directly from Echo Qualified sample tubes, enabling a fully non-contact liquid handling workflow from sample storage all the way to assay ready plates. The Echo 655T Liquid Handler is capable of transferring as little as 2.5 nL from 384-well and 1536-well microplates, and now, from sample tubes arrayed in a 96-tube format. Additionally, it transfers at the highest speed to meet the needs of high-thoughput biochemical and cell-based screening.

Acoustic Technology Video

 

Watch the Echo acoustic droplet ejection (ADE) technology in action. Sound waves eject precisely-sized droplets from the source plate onto the destination plate suspended above.

Echo 650 Series Acoustic Liquid Handler Specifications

Drop volume 2.5 nL
Volume transfer range 2.5 nL – 5 µL (dependent on fluid type, assay, and source plate used)
Reagents supported DMSO, PCR and qPCR reagents, synthetic biology reagents, NGS reagents, primers and probes, cell culture media, proteins, nucleic acids, up to 50% glycerol, serum, plasma, antibodies, enzymes, and protein crystallography reagents
Transfer accuracy <10% deviation from target volume
Transfer precision <8% CV (except protein crystallography fluid class)
Source labware compatibility All Echo Qualified 384- and 1536-well Microplates
Destination labware compatibility All Echo Qualified Microplates and most ANSI-compliant/SBS-standard microplates in 96-, 384-, 1536-, and 3456-well formats 8 to 16 mm well height
Barcode reader options Short-side and/or long-side
Dimensions 53.9 cm width x 68.3 cm depth x 92.5 cm height (21.2 x 26.9 x 36.4 inches)
Weight 130 kg (286 lbs)
Working envelope Additional 25.4 cm (10 inches) on top, 2.5 cm (1 inch) on sides, 7.6 cm (3 inches) at front, 30.5 cm (12 inches) at back
Electrical AC 120V, 50/60 Hz, 10 A or AC 230V, 50/60Hz, 5 A
Operating temperature 21°C ± 5°C (70°F ± 9°F)
Vacuum House supply minimum 200 Torr (266 mbar, 22 inches Hg Vac)
OR
Standalone vacuum with surge tank, minimum pump speed 2.0 m3/hr, minimum pressure 100 Torr (133 mbar, 26 inches Hg Vac)
Fluid class calibration No calibration needed

Content and Resources

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Resource Type
Automation Drug Discovery Brochure Drug discovery is all about the numbers. A sometimes overwhelming amount of numbers. Maintaining traceability of billions of cells or hundreds, maybe thousands of compounds. Library screening and hit identification. Countless hours spent at the bench, followed by dozens more hours spent mining millions of data points.
Echo Series Liquid Handlers Unlike traditional liquid handlers, the Echo system uses sound energy to precisely transfer liquid without contact or using pipette tips, nozzles or tubing. Designed for diverse applications in scientific research, the Echo Liquid Handler combines the innovative technologies of Acoustic Droplet Ejection and Dynamic Fluid Analysis to accurately and reliably transfer a wide range of fluids. Across many scientific disciplines including drug discovery, genomics, synthetic biology, and functional studies,
Echo Acoustic Liquid Handling for Synthetic Biology Advantages of the Echo Liquid Handler in Synthetic Biology Compared to Tip-based Liquid Handlers
Long-Term Compound Storage in Acoustically Enabled Tubes: Theory and Experiment Acoustic transfer of compounds between microplates by Echo liquid handling instruments has facilitated high-throughput drug discovery at a reduced cost.
Host Cell Residual DNA Testing in Reduced Volume qPCR Reactions Using Acoustic Liquid Handling The removal of host cell impurities is a critical step in the production of biopharmaceutical products. One impurity targeted for clearance during the process is residual DNA arising from host cells.